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  3. MK-1084-012/KANDLELIT-012

MK-1084 With Targeted Therapy and Chemotherapy in People With Colorectal Cancer

Short Title: MK-1084-012/KANDLELIT-012


Enrollment Status: Recruiting

NCT #: NCT06997497

Specialty Area: Oncology

Conditions Studied: Colon Adenocarcinoma; Rectal Adenocarcinoma

Age Groups: Adult; Older Adult

Phase: III


Study Information

Summary / Purpose

To find out if adding MK-1084 and cetuximab to standard chemotherapy (mFOLFOX6) helps people with KRAS G12C-mutated colorectal cancer live longer and delay cancer progression compared to usual treatment.

Study Type: Interventional
Accepts Healthy Volunteers: No

Who Can Participate

Eligibility Criteria:
  • Adults 18+ years of age
  • Diagnosed with colorectal cancer that cannot be removed by surgery (unresectable) has spread to nearby tissue or lymph nodes (locally advanced) or to other places in the body (metastatic) (mCRC) and has a KRAS G12C gene mutation
  • Eligible for chemotherapy and targeted therapy
  • Cannot have active inflammatory bowel disease requiring immunosuppressive medication or previous clear history of inflammatory bowel disease

What's Involved

Participation in the study will include:
  • Treatment with targeted therapies MK-1084 given orally and cetuximab given intravenously (IV)
  • Chemotherapy with mFOLFOX6 (includes oxaliplatin, leucovorin, and 5-fluorouracil) given intravenously (IV)
  • Some participants may also receive bevacizumab given intravenously (IV)
  • Blood tests and imaging to monitor response to treatment
  • Questionnaires

Principal Investigator

Additional Information

Location: Renown Health, Office of Clinical Research
Address:

1500 E 2nd St. Reno, NV 89502

General Research: 775-982-3646
Oncology Research: 775-982-5050
Email: Renown-CRD@renown.org

Complete Study Details: https://clinicaltrials.gov/study/NCT06997497

Disclaimer: This listing gives you general information about the study and isn't part of the official consent process. If you decide to learn more, the research team will talk with you and check if you meet any additional requirements to join the study.

ER Wait Times

How are wait times calculated?

Our estimated ER wait times reflect the average time from check-in to being seen by a medical professional during triage, where patients are prioritized based on the severity of their condition.

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