Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

To determine if open surgical resection is superior to thoracoscopic resection for thoracic event-free survival in patients with resectable oligometastatic pulmonary osteosarcoma.

• Children and Adults 0-50 years of age
• Must have < 4 nodules per lung consistent with or suspicious for metastases, with at least one of which being > 3 mm and all of which must be < 3 cm size
• Lung nodules must be considered resectable by either open thoracotomy or thoracoscopic surgery
• Must have a histological diagnosis of osteosarcoma
• Must have evidence of metastatic lung disease at the time of initial diagnosis, or at time of 1st recurrence following completion of therapy for initially localized disease

• Thoracic surgery (thoracotomy) or Video-assisted thoracoscopic surgery (thoracoscopy)
• Tissue and blood samples
• Computed Tomography (CT) scan
• Questionnaire