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Trastuzumab Deruxtecan, Pembrolizumab, and Platinum-based Chemotherapy in First-line HER2 Overexpressing Non-small Cell Lung Cancer

Short Title: DESTINY-Lung06


Enrollment Status: Recruiting

NCT #: NCT06899126

Specialty Area: Oncology

Condition Studied: Locally Advanced Unresectable or Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

Age Groups: Adult; Older Adult

Phase: III


Study Information

Summary / Purpose

To find out if trastuzumab deruxtecan combined with pembrolizumab works better than platinum-based chemotherapy with pembrolizumab in treating HER2-overexpressing advanced or metastatic non-small cell lung cancer.

Study Type: Interventional
Accepts Healthy Volunteers: No

Who Can Participate

Eligibility Criteria:
  • Adults 18+ years of age
  • Diagnosed with non-squamous Non-Small Cell Lung Cancer (NSCLC)
  • Cancer must be HER2-overexpressing
  • PD-L1 tumor proportion score (TPS) less than 50%
  • No prior treatment for advanced or metastatic NSCLC
  • No known actionable genetic alterations with available targeted therapies

What's Involved

Participation in the study will include:
  • Treatment with trastuzumab deruxtecan and pembrolizumab given intravenously (IV), or platinum-based chemotherapy and pembrolizumab given intravenously (IV)
  • Imaging tests to monitor response to treatment
  • Blood tests to monitor your health and treatment effects
  • Questionnaires

Principal Investigator

Additional Information

Location: Renown Health, Office of Clinical Research
Address:

1500 E 2nd St. Reno, NV 89502

General Research: 775-982-3646
Oncology Research: 775-982-5050
Email: Renown-CRD@renown.org

Complete Study Details: https://clinicaltrials.gov/study/NCT06899126

Disclaimer: This listing gives you general information about the study and isn't part of the official consent process. If you decide to learn more, the research team will talk with you and check if you meet any additional requirements to join the study.

ER Wait Times

How are wait times calculated?

Our estimated ER wait times reflect the average time from check-in to being seen by a medical professional during triage, where patients are prioritized based on the severity of their condition.

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