Adaptive Radiation and Chemotherapy for Muscle Invasive Bladder Cancer

To find out if a shorter course of radiation therapy works as well as the usual radiation schedule when combined with chemotherapy for bladder cancer.

• Adults 18+ years of age
• Diagnosed with muscle-invasive bladder cancer
• Must be eligible to receive chemotherapy with cisplatin, gemcitabine, mitomycin, or 5-fluorouracil (5-FU)
• Must be able to undergo radiation therapy
• No prior pelvic radiation or treatments that would interfere with study participation

• Treatment with either shorter duration radiation therapy (ultra-hypofractionated) OR standard radiation therapy (hypofractionated)
• Chemotherapy with cisplatin, gemcitabine, mitomycin, or 5-fluorouracil (5-FU) given intravenously (IV)
• CT scans, MRI, and PET scans to monitor response to treatment
• Blood and tissue sample collection to monitor your health and treatment effects
• Questionnaires