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  3. C4391024/FOURLIGHT-3

PF-07220060 With Letrozole in Adults With HR-positive HER2-negative Breast Cancer

Short Title: C4391024/FOURLIGHT-3


Enrollment Status: Recruiting

NCT #: NCT06760637

Specialty Area: Oncology

Condition Studied: Locally Advanced or Metastatic Breast Cancer

Age Groups: Adult; Older Adult

Phase: III


Study Information

Summary / Purpose

To find out if PF-07220060 plus letrozole is safe and effective compared to approved treatments (palbociclib, ribociclib, or abemaciclib) plus letrozole in people with HR+/HER2− breast cancer who have not yet received treatment for advanced or metastatic disease.

Study Type: Interventional
Accepts Healthy Volunteers: No

Who Can Participate

Eligibility Criteria:
  • Adults 18+ years of age
  • Diagnosed with hormone receptor-positive (HR+), HER2-negative breast cancer that has spread to nearby tissue or lymph nodes (locally advanced) or spread beyond the breast (metastatic)
  • No prior systemic anti-cancer treatment for advanced or metastatic disease

What's Involved

Participation in the study will include:
  • PF-07220060 or an approved treatment (palbociclib, ribociclib, or abemaciclib) given orally plus letrozole given orally
  • CT/MRI scans to check response to treatment
  • Blood and urine tests to monitor your health and treatment effects
  • Electrocardiogram (ECG) to monitor heart function
  • Questionnaires

Principal Investigator

Additional Information

Location: Renown Health, Office of Clinical Research
Address:

1500 E 2nd St. Reno, NV 89502

General Research: 775-982-3646
Oncology Research: 775-982-5050
Email: Renown-CRD@renown.org

Complete Study Details: https://clinicaltrials.gov/study/NCT06760637

Disclaimer: This listing gives you general information about the study and isn't part of the official consent process. If you decide to learn more, the research team will talk with you and check if you meet any additional requirements to join the study.

ER Wait Times

How are wait times calculated?

Our estimated ER wait times reflect the average time from check-in to being seen by a medical professional during triage, where patients are prioritized based on the severity of their condition.

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