SALA DE PRENSA DE RENOWN

Clinical researchers with the Healthy Nevada Project co-author research paper with findings that emphasize the need for a comprehensive approach to breast cancer risk assessment – including a focus on genetic medicine – to help ensure that individuals at high risk are identified and supported proactively rather than reactively.  Breast cancer is a leading cause of cancer death among women in the United States. According to the American Cancer Society, about 1 in 8 women will develop breast cancer and about 1 in 39 women will die from breast cancer. Breast cancer is associated with increased age, hereditary factors, obesity, and alcohol use. Since 1990, breast cancer death rates have declined progressively due to advancements in treatment and detection. In Nevada there are an estimated 2,310 new breast cancer cases a year, and genetic mutations such as in the genes BRCA1 or BRCA2 remain a top risk factor for this prevalent disease. Recognizing the urgency for progress in breast cancer research, a collaborative effort between physicians, advanced practice providers and scientists from the Healthy Nevada Project® (HNP) and Helix have unveiled groundbreaking research. This study explores how genetic screenings are a necessary supplement to traditional testing methods, together offering more accurate insights into a patient's likelihood of developing breast cancer in the future. HNP is operated by Renown Genomic Medicine and the Institute for Health Innovation and is one of the largest community-based population health studies in the country. Their team works in collaboration with Helix, a leader in precision health that delivers comprehensive genomic solutions. Together, this dynamic partnership aims to understand breast cancer risk factors and pave the way for more effective preventative measures. The combined research team studied 25,591 female HNP participants to evaluate the performance of different genetic screening approaches to identify women at high risk of breast cancer. The results of this research suggest that a combined monogenic, or single-gene, and polygenic, or multi-gene, approach to breast cancer screenings helped produce more accurate results and more closely identify study participants who have a high genetic risk of developing the disease. "Based on this research, we are advocating a shift in approach which would improve breast cancer risk assessment through a combination of effective family history ascertainment and genetic screening,” said Joseph Grzymski, PhD, principal investigator of the Healthy Nevada Project, research professor at the University of Nevada, Reno School of Medicine and co-author of the breast cancer research paper. “This tailored approach, founded on the assessment of individual genetic risk, not only intends to elevate patient well-being but also will improve efficiency and equity in healthcare." Complementing the team’s research on leveraging genetics to identify women at low genetic risk of breast cancer that could safely defer mammogram screenings by five to 10 years that was released in late 2023 in JAMA Oncology, the study suggests that incorporating genetic information can assist in personalizing breast cancer screenings and optimizing the use of screening resources. "Existing disparities persist across various facets of breast cancer screening and treatment; however, genetic screening is clearly a powerful tool to help facilitate early intervention for those at higher risk,” said Jamie Schnell Blitstein, APRN, a primary care nurse practitioner at Renown Health and co-author of the breast cancer research paper. “By placing a heightened focus on risk, we underscore the pivotal role of preventative breast cancer screening.” Despite the availability of effective methods for early screening, co-authors of this research found that 78 percent of women with a family history of breast cancer had their risk ascertained only after a breast cancer diagnosis. The findings emphasize the need for a comprehensive approach to breast cancer risk assessment – including a focus on genetic medicine – to help ensure that individuals at high risk are identified and supported proactively rather than reactively.  “These findings that can profoundly impact how healthcare is delivered were only made possible by all the participants who were willing to consent to research,” said Alex Bolze, PhD from Helix and co-author of the publication. “Broad-scale collaboration projects like these between Renown Health and UNR that engage large populations where participants share both their genetic information as well as electronic health records drive advancements in preventative medicine, as well as fundamental biological research.”   The research paper was officially accepted on Jan. 29, 2024, and will be published by Elsevier, Inc. on behalf of the American College of Medical Genetics and Genomics. The contents of the paper will appear in the international journal Genetics in Medicine Open. Read the full article by visiting sciencedirect.com. The Healthy Nevada Project is currently recruiting new study participants. Free to all Nevadans with a saliva sample or blood draw, participants and their referring providers receive access to whole-exome sequencing and clinical grade results that help provide insight into their unique genetic risks tied to heart disease and certain cancers. If you are interested in enrolling in the study, schedule a Virtual Consent Appointment through MyChart or contact the Renown Institute for Health Innovation at RenownIHI@renown.org or (775) 982-6914 to be connected to a Genomic Representative. About Renown Health Renown Health is the region’s largest, not-for-profit integrated healthcare network serving Nevada, Lake Tahoe and northeast California. Con una fuerza laboral diversa de más de 7,000 empleados, Renown ha fomentado una cultura de excelencia, determinación e innovación de larga data. La organización se compone de un centro de urgencias, dos hospitales de cuidados agudos, un hospital infantil, un hospital de rehabilitación, un grupo médico y una red de atención de urgencias y Hometown Health, la compañía de seguros sin fines de lucro más grande de la región y de propiedad local, Hometown Health. Renown is currently enrolling participants in the largest community-based genetic population health study, the Healthy Nevada Project®. To join the Renown Health team, visit renown.org/careers. Acerca de Helix Helix es la compañía líder en genómica y vigilancia viral de la población cuyas operaciones se basan en el cuidado clínico, la investigación y el análisis de datos. Helix enables health systems, life sciences companies, payers, and government partners to accelerate the integration of genomic data into patient care and public health decision-making. Learn more at helix.com.

Leer más About Research Shows Genetic Approaches to Breast Cancer Screenings Yield More Accurate Results

Expanded test processing capabilities is resulting in faster test results, lessening the load on the state lab, and helping keep patients, care providers and the community safe. Renown Health anunció hoy que su laboratorio interno ahora puede procesar hasta 500 pruebas de detección de COVID-19 por día para pacientes hospitalizados y proveedores de atención médica. The organization has invested in expanded test processing capabilities to better serve the community amid the coronavirus pandemic, and to increase testing available across the state. El próximo mes, Renown prevé continuar con la ampliación de la capacidad de prueba y duplicarla para poder procesar 1,000 pruebas por día en preparación para dar una respuesta continua a la pandemia. “The COVID-19 pandemic is not going away- it is still with us. I am concerned by the number of new cases and hospitalizations we are seeing across northern Nevada. We must do more testing. We need broader capabilities around making sure we have broad-scale surge testing available, so we can help people identify if they have COVID-19 or not,” said Tony Slonim, MD, DrPH, Renown’s President & CEO. “Si pudiéramos hacer pruebas de detección de COVID-19 a 60,000 personas del norte de Nevada, como hicimos para el Healthy Nevada Project, podríamos entender mejor con datos y hechos la proporción de personas que realmente tienen COVID-19 frente a las que solo tienen catarro y un resfriado”. Lanzado en 2016, el Healthy Nevada Project https://healthynv.org/ es un estudio poblacional basado en la comunidad en el que se ofrecen pruebas genéticas gratuitas a miles de residentes de Nevada para obtener información sobre la salud de la comunidad y conocer los riesgos genéticos de cada persona. Desde el martes, 2,286 personas del norte de Nevada se han sometido a pruebas, y los casos positivos rondaron los 700. Setenta y cuatro personas en el norte de Nevada fallecieron y 1,526 se recuperaron. https://www.washoecounty.us/ El Dr. Slonim dice que las pruebas lo ayudarían a él y a otras personas a tomar decisiones y elaborar planes importantes para el coronavirus con evidencia. He wants to be able to test many more individuals across northern Nevada. “Testing is pivotal upstream, so you can prevent consequences downstream,” said Dawn D. Ahner, DSc, FACHE, Chief Operating Officer – Renown Acute Services. “Al procesar nuestras propias pruebas, hemos reducido el plazo para recibir los resultados a solo 12 o 24 horas, lo que tendrá un impacto profundamente positivo en nuestra comunidad y alivia la carga en el laboratorio estatal. “Testing is an incredibly important tool in our fight against coronavirus,” said Tim Stephens, vice president of ancillary services. “No hay una prueba 100 % perfecta; sin embargo, las pruebas de PCR son tan sensibles que, cuando se realizan a la perfección, tienen una tasa de falsos positivos muy baja. Certified labs like Renown’s use a number of procedures to reduce the risk of false test results.” “The expansion of our lab’s new testing capabilities during this time is a testament to the innovative and important work being done here at Renown,” said Erik Olson, CEO of Renown Regional Medical Center. “Throughout the pandemic, our ancillary team, which includes services like laboratory, radiology and pharmacy, has been quick to adapt to the needs of our patients and our community. I am pleased that we are able to generate critical test results for patients and providers as we continue the fight against COVID-19 and go the extra mile for safety.”   Going the extra mile for safety As an added safety measure, acute hospital patients; patients preparing for surgery, and care providers who may have come into contact with those positive for COVID-19, are among those that receive mandatory PCR testing from Renown at this time. For patients receiving hospital care, these tests help determine if patients should be placed in a designated area of the hospital to mitigate the risk of transmission to those not infected. Furthermore, all surgery patients are tested ahead of their surgery and self-quarantine prior to their surgical procedure at Renown Regional Medical Center and Renown South Meadows Medical Center. How do PCR tests work? PCR tests use a sample of mucus typically taken from a person's nose or throat. The test looks for the genetic material of the coronavirus, using a technology called PCR to detect if the viral genetic material is present. Those actively infected with the virus will show the existence of that material. Se recomienda a las personas que crean que deben hacerse la prueba de detección de COVID-19 que llamen a su proveedor médico o se comuniquen con el Distrito de Salud del Condado de Washoe al 775-328-2427 para una evaluación de riesgos. For up-to-date information on Renown’s approach to keeping our community safe, visit our website at renown.org/covid-19/.   Please see b-roll for this story here.     About Renown Health Renown Health is a locally governed and locally owned, not-for-profit integrated healthcare network serving northern Nevada, Lake Tahoe and northeast California. Renown es uno de los mayores empleadores privados de la región y cuenta con una fuerza laboral de más de 7,000. It comprises three acute care hospitals, Renown Children’s Hospital, Renown Rehabilitation Hospital, the area’s most comprehensive medical group and urgent care network, and the region’s largest and only locally owned not-for-profit insurance company, Hometown Health. Renown has a long tradition and commitment to continually improve the care and the health of our community. Visite renown.org para obtener más información.

Leer más About El laboratorio interno de Renown Health ya procesa las pruebas de detección de COVID-19 para los pacientes y proveedores de atención médica