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    • Miércoles, 06 de marzo de 2024

    Research Shows Genetic Approaches to Breast Cancer Screenings Yield More Accurate Results

    Clinical researchers with the Healthy Nevada Project co-author research paper with findings that emphasize the need for a comprehensive approach to breast cancer risk assessment – including a focus on genetic medicine – to help ensure that individuals at high risk are identified and supported proactively rather than reactively.  Breast cancer is a leading cause of cancer death among women in the United States. According to the American Cancer Society, about 1 in 8 women will develop breast cancer and about 1 in 39 women will die from breast cancer. Breast cancer is associated with increased age, hereditary factors, obesity, and alcohol use. Since 1990, breast cancer death rates have declined progressively due to advancements in treatment and detection. In Nevada there are an estimated 2,310 new breast cancer cases a year, and genetic mutations such as in the genes BRCA1 or BRCA2 remain a top risk factor for this prevalent disease. Recognizing the urgency for progress in breast cancer research, a collaborative effort between physicians, advanced practice providers and scientists from the Healthy Nevada Project® (HNP) and Helix have unveiled groundbreaking research. This study explores how genetic screenings are a necessary supplement to traditional testing methods, together offering more accurate insights into a patient's likelihood of developing breast cancer in the future. HNP is operated by Renown Genomic Medicine and the Institute for Health Innovation and is one of the largest community-based population health studies in the country. Their team works in collaboration with Helix, a leader in precision health that delivers comprehensive genomic solutions. Together, this dynamic partnership aims to understand breast cancer risk factors and pave the way for more effective preventative measures. The combined research team studied 25,591 female HNP participants to evaluate the performance of different genetic screening approaches to identify women at high risk of breast cancer. The results of this research suggest that a combined monogenic, or single-gene, and polygenic, or multi-gene, approach to breast cancer screenings helped produce more accurate results and more closely identify study participants who have a high genetic risk of developing the disease. "Based on this research, we are advocating a shift in approach which would improve breast cancer risk assessment through a combination of effective family history ascertainment and genetic screening,” said Joseph Grzymski, PhD, principal investigator of the Healthy Nevada Project, research professor at the University of Nevada, Reno School of Medicine and co-author of the breast cancer research paper. “This tailored approach, founded on the assessment of individual genetic risk, not only intends to elevate patient well-being but also will improve efficiency and equity in healthcare." Complementing the team’s research on leveraging genetics to identify women at low genetic risk of breast cancer that could safely defer mammogram screenings by five to 10 years that was released in late 2023 in JAMA Oncology, the study suggests that incorporating genetic information can assist in personalizing breast cancer screenings and optimizing the use of screening resources. "Existing disparities persist across various facets of breast cancer screening and treatment; however, genetic screening is clearly a powerful tool to help facilitate early intervention for those at higher risk,” said Jamie Schnell Blitstein, APRN, a primary care nurse practitioner at Renown Health and co-author of the breast cancer research paper. “By placing a heightened focus on risk, we underscore the pivotal role of preventative breast cancer screening.” Despite the availability of effective methods for early screening, co-authors of this research found that 78 percent of women with a family history of breast cancer had their risk ascertained only after a breast cancer diagnosis. The findings emphasize the need for a comprehensive approach to breast cancer risk assessment – including a focus on genetic medicine – to help ensure that individuals at high risk are identified and supported proactively rather than reactively.  “These findings that can profoundly impact how healthcare is delivered were only made possible by all the participants who were willing to consent to research,” said Alex Bolze, PhD from Helix and co-author of the publication. “Broad-scale collaboration projects like these between Renown Health and UNR that engage large populations where participants share both their genetic information as well as electronic health records drive advancements in preventative medicine, as well as fundamental biological research.”   The research paper was officially accepted on Jan. 29, 2024, and will be published by Elsevier, Inc. on behalf of the American College of Medical Genetics and Genomics. The contents of the paper will appear in the international journal Genetics in Medicine Open. Read the full article by visiting sciencedirect.com. The Healthy Nevada Project is currently recruiting new study participants. Free to all Nevadans with a saliva sample or blood draw, participants and their referring providers receive access to whole-exome sequencing and clinical grade results that help provide insight into their unique genetic risks tied to heart disease and certain cancers. If you are interested in enrolling in the study, schedule a Virtual Consent Appointment through MyChart or contact the Renown Institute for Health Innovation at RenownIHI@renown.org or (775) 982-6914 to be connected to a Genomic Representative. About Renown Health Renown Health is the region’s largest, not-for-profit integrated healthcare network serving Nevada, Lake Tahoe and northeast California. Con una fuerza laboral diversa de más de 7,000 empleados, Renown ha fomentado una cultura de excelencia, determinación e innovación de larga data. La organización se compone de un centro de urgencias, dos hospitales de cuidados agudos, un hospital infantil, un hospital de rehabilitación, un grupo médico y una red de atención de urgencias y Hometown Health, la compañía de seguros sin fines de lucro más grande de la región y de propiedad local, Hometown Health. Renown is currently enrolling participants in the largest community-based genetic population health study, the Healthy Nevada Project®. To join the Renown Health team, visit renown.org/careers. Acerca de Helix Helix es la compañía líder en genómica y vigilancia viral de la población cuyas operaciones se basan en el cuidado clínico, la investigación y el análisis de datos. Helix enables health systems, life sciences companies, payers, and government partners to accelerate the integration of genomic data into patient care and public health decision-making. Learn more at helix.com.

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    • Jueves, 17 de diciembre de 2020

    First COVID-19 Vaccines Administered to Physicians Today

    This week, many of the nation’s health care systems in communities across the U.S. began vaccinating physicians and health care workers caring for patients with COVID-19. Many of these health care heroes have been on the front-line of this pandemic and working around-the clock over the last ten months. Las vacunas son una señal de esperanza para el futuro Aquí, en el condado de Washoe, hoy marca el muy deseado inicio de lo que los expertos en salud pública y medicina esperan que sea una ola nacional de vacunas que señale el comienzo del final de la pandemia de la COVID-19. La buena noticia de hoy de Renown coincidió con un nuevo hito negativo para el condado de Washoe: 384 muertes por COVID-19 confirmadas y más de 13,579 casos activos en una población de casi 500,000 personas. COVID-19 positivity test results and hospitalizations continue to be high across the country, our state and here in northern Nevada; straining hospital capacity, physicians and healthcare workers.  Today we saw a bright light at the end of this dark tunnel. Renown began vaccinating health care workers caring for patients with COVID-19, and invited media to view the first vaccinations of those on the front-line of COVID-19. One vaccine, a Herculean effort of thousands “Although the vaccination process as you see it here looks relatively simple, it took a herculean logistical effort to implement the COVID-19 vaccination process that has begun today,” said Tony Slonim, MD, DrPH, President & CEO of Renown Health. “Today, thanks to the synchronized efforts of thousands of people and organizations across the country, we give thanks for this vaccination provided to Luis Martinez, an excellent ambassador for the thousands of healthcare heroes caring for patients with COVID-19. The health and safety of our staff is our top priority, and we remain steadfast in our determination to fight the good fight for our community.”  Luis, on the front-line of the COVID-19 pandemic, receives 1st vaccine from Renown Luis Martinez received the 1st of his Pfizer-BioNTech vaccine which received emergency use authorization from the Food and Drug Administration last week. Recibirá la segunda y última vacuna de la serie en 21 días. La primera dosis de la vacuna se le administró a Luis fuera de su vehículo para que las cámaras pudieran capturar la experiencia. El proceso de vacunación contra la COVID-19 de Renown incluye programar previamente a médicos y empleados mediante el registro médico electrónico EPIC MyChart que usa Renown. Employees are masked, and in their personal vehicles, as they drive through the vaccination site. Each physician and healthcare worker provides their verification, identification, documentation and consent. They then extend their upper arm to receive the Pfizer vaccination. Following the receipt of the vaccination they have a 15-minute observation period to assure they do not experience any immediate side effects. These Tier 1A healthcare employees were encouraged to schedule their vaccination after their completed work schedule to have time to rest. As with all vaccinations, there is a potential for injection site reactions (redness, swelling and pain) as well as fever, fatigue, headache, chills, vomiting, diarrhea, muscle pain and/or joint pain. Fever is not an infrequent side effect, especially on the 2nd dose, so these vaccinated employees will self-monitor their temperatures, as they cannot work at Renown with a fever. Además de Luis, verá, primero en su camión el Dr. Bret Frey, que representa al personal médico y a los médicos de emergentología de Renown; el enfermero Matt Polak, supervisor de Enfermería Clínica de la Unidad de Cuidados Intensivos Respiratorios de Renown; Holly Irwin, terapeuta clínica de enfermedades respiratorias en su vehículo; Alexis Bertauche, especialista en enfermedades respiratorias en su vehículo; Eric Whitney, el supervisor que representa a los 168 miembros del equipo de Servicios Ambientales de Renown que han implementado grandes medidas de desinfección durante toda la pandemia; médicos representantes de socios de la Facultad de Medicina de la UNR, de la Reno Orthopedic Clinic, del Surgery Center of Reno y de toda la comunidad. Un futuro más prometedor para Luis Luis ha estado trabajando en el Renown’s Alternate Care Site, en la estructura de estacionamiento de Mill Street desde que se inauguró para atender pacientes a mediados de noviembre. Ha estado en Renown desde 2016, donde comenzó como flebotomista y lo alentaron a seguir una carrera profesional en el campo de la medicina. He applied to work as a technician on Renown’s Clinical Decision Unit- a short stay unit within the hospital for people who need clinical care, but do not need to be admitted to the hospital. Luis worked with patients and clinicians in the Clinical Decision Unit for a year before requesting to work in Renown’s innovative Alternate Care Site, built for patients recovering from COVID-19, for additional care before they returned home. Luis was scheduled to take the Medical College Admission Test® in April of this year to fulfill his dreams of becoming a doctor, but the COVID-19 pandemic forced him to change his plans. He plans to reschedule his medical school admission exam in February. He is excited to begin his training, possibly at UNR School of Medicine, and hopes one day to be a physician caring competently and compassionately for those in need.  Luis has so much to look forward to, after such a difficult year. Luis cumplió 33 años en octubre y, en su cumpleaños, se contagió de COVID-19 después de asistir a una fiesta familiar. He experienced fever and noticed how dramatically the COVID-19 virus affected his breathing, his lungs, and his energy level. After spending time at home recovering, Luis recovered, tested negative, and returned to work. Como resultado de su experiencia y su interés en la medicina, Luis ha investigado mucho sobre la vacuna. Luis es bilingüe y es voluntario de CARE Chest de Sierra Nevada, una organización sin fines de lucro que proporciona equipos y suministros médicos, y asistencia con recetas de forma gratuita a poblaciones marginadas, cuando no trabaja en Renown. La vacuna: una herramienta más para ayudar a combatir la pandemia: “La mejor protección contra la COVID-19 será una combinación de vacunarse contra la COVID-19, usar mascarilla, mantenerse al menos a 6 pies de distancia de otras personas, evitar las multitudes y lavarse las manos con frecuencia”, dice Amy McCombs, máster en enfermería, enfermera certificada, CCRN, CNML, vicepresidenta de Calidad de Servicios Agudos de Renown y líder en el esfuerzo de vacunación de Renown. “No one tool alone will stop this pandemic, it will take a combination of all of us using all of these efforts to fight the spread of this virus. Though there has been positive news about vaccine development, no one knows when those vaccines will be ready for widespread use. In the meantime, everyone must remain vigilant, take precautions and follow public health orders.”  “This vaccination is a game-changer in terms of improving the health of our community,” said Paul Sierzenski, MD, MSHQS, Chief Medical Officer, Acute Services, Renown Health. "Given the demands of this COVID-19 pandemic, we are pleased to be able to provide this vaccination to help in the fight. We will follow CDC recommendations for a tiered approach to vaccine distribution. Our goal is that by spring, all Renown physicians; employees and their family members; and all Hometown Health members and Renown patients interested in receiving the vaccine will have an opportunity to be vaccinated.” The COVID-19 vaccine is not mandatory for all Renown employees, but is strongly advised. Renown is covering all costs of the vaccine, and it is being offered free of charge to employees. Regístrese en Renown EPIC MyChart ahora. Para simplificar el proceso de notificación, consentimiento, programación y recordatorio para la distribución de vacunas, y para publicar en el sistema estatal de información de inmunización Web IZ de Nevada, las personas que estén interesadas en recibir la vacuna a través de Renown tendrán que registrarse y obtener una cuenta EPIC MyChart. Manténgase actualizado sobre la COVID-19 Renown Health está preparada para evaluar, diagnosticar y atender de manera segura a pacientes con enfermedad respiratoria, incluida la COVID-19. Para mantenerse actualizado sobre las comunicaciones relacionadas con la distribución de la vacuna contra la COVID-19 por parte de Renown, las preguntas frecuentes y la evidencia científica detrás de la vacuna, visite https://covid.renown.org/  Únase al equipo de Renown Renown Health continúa comprometido con la contratación de personas para ocupar puestos clave en la organización para apoyar la salud y el bienestar de nuestra comunidad. Para unirse a la familia de Renown y luchar por la causa justa, postule en línea en https://careers.renown.org/ Apoye al equipo de Renown Renown Health, una organización benéfica sin fines de lucro, está muy agradecida por el apoyo de la comunidad durante estos momentos sin precedentes. Para donar a pacientes o proveedores de Renown, visite https://www.renown.org/donations-covid-19/.   About Renown Health Renown Health is a locally governed and locally owned, not-for-profit integrated healthcare network serving northern Nevada, Lake Tahoe and northeast California. Renown es uno de los mayores empleadores privados de la región y cuenta con una fuerza laboral de más de 7,000. It comprises three acute care hospitals, a rehabilitation hospital, the area’s most comprehensive medical group and urgent care network, and the region’s largest and only locally owned not-for-profit insurance company, Hometown Health. Renown has a long tradition and commitment to continually improve the care and the health of our community. Visite renown.org para obtener más información. About the Washoe County Health District The Washoe County Health District has jurisdiction over all public health matters in Reno, Sparks, and Washoe County through the policy-making Washoe County District Board of Health. The District consists of five divisions: Administrative Health Services, Air Quality Management, Community and Clinical Health Services, Environmental Health Services and Epidemiology & Public Health Preparedness. More info can be found here.

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